Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1.
PARP inhibitors are currently being used in clinical trials to treat BRCA1- or BRCA2-defective tumors, based on the synthetic lethal interaction between PARP1 and BRCA1/2-mediated homologous recombination (HR). However, the molecular mechanisms that drive this synthetic lethality remain unclear. Her...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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