Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model

Salmonella Typhi is a human host-restricted pathogen that is responsible for typhoid fever in approximately 10.9 million people annually1. The typhoid toxin is postulated to have a central role in disease pathogenesis, the establishment of chronic infection and human host restriction2-6. However, it...

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Bibliographic Details
Main Authors: Gibani, M, Jones, E, Barton, A, Jin, C, Meek, J, Camara, S, Galal, U, Heinz, E, Rosenberg-Hasson, Y, Obermoser, G, Jones, C, Campbell, D, Black, C, Thomaides-Brears, H, Darlow, C, Dold, C, Silva-Reyes, L, Blackwell, L, Lara-Tejero, M, Jiao, X, Stack, G, Blohmke, C, Hill, J, Angus, B, Dougan, G, Galán, J, Pollard, A
Format: Journal article
Language:English
Published: Springer Nature 2019