Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses

Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, as this is highly predictive of virus contro...

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Bibliographic Details
Main Authors: Hancock, G, Yang, H, Yorke, E, Wainwright, E, Bourne, V, Frisbee, A, Payne, T, Berrong, M, Ferrari, G, Chopera, D, Hanke, T, Mothe, B, Brander, C, McElrath, M, McMichael, A, Goonetilleke, N, Tomaras, G, Frahm, N, Dorrell, L
Format: Journal article
Language:English
Published: Public Library of Science 2015