Cilia-associated oxysterols activate Smoothened

Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we identify cilia-associated oxysterols that promote Smoothened accumulation in cilia and activate the Hedgehog pathway. Our...

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Bibliographic Details
Main Authors:	Raleigh, DR, Sever, N, Choksi, PK, Sigg, MA, Hines, KM, Thompson, BM, Elnatan, D, Jaishankar, P, Bisignano, P, Garcia-Gonzalo, FR, Krup, AL, Eberl, M, Byrne, EFX, Siebold, C, Wong, SY, Renslo, AR, Grabe, M, McDonald, JG, Xu, L, Beachy, PA, Reiter, JF
Format:	Journal article
Language:	English
Published:	Cell Press 2018

Cilia-associated oxysterols activate Smoothened

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