Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide

<p><strong>Aims</strong><br> Atrial fibrillation (AF) is the most common cardiac arrhythmia. Pathogenic variants in genes encoding ion channels are associated with familial AF. The point mutation M1875T in the SCN5A gene, which encodes the α-subunit of the cardiac sodium chan...

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Bibliographic Details
Main Authors:	O'Reilly, M, Sommerfeld, LC, O'Shea, C, Broadway-Stringer, S, Andaleeb, S, Reyat, JS, Kabir, SN, Stastny, D, Malinova, A, Delbue, D, Fortmueller, L, Gehmlich, K, Pavlovic, D, Skryabin, BV, Holmes, AP, Kirchhof, P, Fabritz, L
Format:	Journal article
Language:	English
Published:	Oxford University Press 2022

Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide

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