Rigid body essential X-ray crystallography: distinguishing the bend and twist of glutamate receptor ligand binding domains.

The ligand-binding domain (LBD) from the ionotropic glutamate receptor subtype 2 (GluR2) has been shown to adopt a range of ligand-dependent conformational states. These states have been described in terms of the rotation required to fit subdomain (lobe) 2 following superposition of subdomain (lobe)...