Paradoxical prolongation of QT interval during exercise in patients with HCM: Cellular mechanisms and implications for diastolic function

Aims Ventricular cardiomyocytes from Hypertrophic Cardiomyopathy (HCM) patient hearts show prolonged action potential duration (APD), impaired intracellular Ca2+ homeostasis and abnormal electrical response to beta -adrenergic stimulation. We sought to determine whether this behavior is associated w...

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Bibliographic Details
Main Authors: Coppini, R, Beltrami, M, Doste, R, Bueno Orovio, A, Ferrantini, C, Vitale, G, Manuel Pioner, J, Santini, L, Argirò, A, Berteotti, M, Mori, F, Marchionni, N, Stefàno, P, Cerbai, E, Poggesi, C, Olivotto, I
Format: Journal article
Language:English
Published: Oxford University Press 2022