An investigation of the role of mutations in the spliceosome machinery in the myelodysplastic syndromes
The myelodysplastic syndromes (MDS) are common myeloid malignancies. Mutations in splicing factor genes (including SF3B1, SRSF2 and U2AF1) occur in over half of MDS patients and result in aberrant pre-mRNA splicing of many target genes, indicating that aberrant spliceosome function plays a key role...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
2022
|