Conformational flexibility influences structure–function relationships in nucleic acid N-methyl demethylases
N-Methylation of DNA/RNA bases can be regulatory or damaging and is linked to diseases including cancer and genetic disorders. Bacterial AlkB and human FTO are DNA/RNA demethylases belonging to the Fe(II) and 2-oxoglutarate oxygenase superfamily. Modelling studies reveal conformational dynamics infl...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2019
|