Synthesis of homorhamnojirimycins and related trihydroxypipecolic acid derivatives via divergent bicyclic amino lactone intermediates: Inhibition of naringinase (L-rhamnosidase) and dTDP-rhamnose biosynthesis

A series of homorhamnqjirimycins and related compounds are prepared from two epimeric [2.2.2] bicyclic amino lactones 6 and 7 via the 2-azidoheptono-l,5-lactone 8, itself derived from L-rhamnose. Aminolysis and deprotection of the bicyclic lactones provides an efficient route to trihydroxypipecolic...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Shilvock, J, Wheatley, JR, Nash, R, Watson, A, Griffiths, R, Butters, T, Muller, M, Watkin, D, Winkler, D, Fleet, G
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: 1999