Transcriptional changes are regulated by metabolic pathway dynamics but decoupled from protein levels

Transcription is necessary for the synthesis of new proteins, often leading to the assumption that changes in transcript levels lead to changes in protein levels which directly impact a cell’s phenotype. Using a synchronized biological rhythm, we show that despite genome-wide partitioning of transcr...

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Bibliographic Details
Main Authors: Feltham, JE, Xi, S, Murray, SC, Wouters, M, Urdiain-Arraiza, J, Heilig, R, George, C, Townley, AF, Roberts, E, Kessler, BM, Liberatori, S, Charles, PD, Angel, A, Fischer, R, Jane Mellor
Format: Journal article
Language:English
Published: Cold Spring Harbor Laboratory 2019