Reprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1

Despite breakthroughs in immune checkpoint inhibitors (ICI), the majority of tumors, including those poorly infiltrated by CD8+ T cells or heavily infiltrated by immunosuppressive immune effector cells, are unlikely to result in clinically meaningful tumor responses. Radiation therapy (RT) has been...

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Bibliographic Details
Main Authors: Mukherjee, D, Romano, E, Walshaw, R, Zeef, LAH, Banyard, A, Kitcatt, SJ, Cheadle, EJ, Tuomela, K, Pendharkar, S, Al-Deka, A, Salerno, B, Raby, S, Mills, IG, Honeychurch, J, Illidge, TM
Format: Journal article
Language:English
Published: Taylor & Francis 2023