Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune system. When the TCR engages a peptide bound to the restricting major histocompatibility complex molecule (pMHC), it transmits a signal via the associated CD3 complex. How the extracellular antigen recognition even...

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Bibliographic Details
Main Authors: Pageon, SV, Tabarin, T, Yamamoto, Y, Ma, Y, Nicovich, PR, Bridgeman, JS, Cohnen, A, Benzing, C, Gao, Y, Crowther, MD, Tungatt, K, Dolton, G, Sewell, AK, Price, DA, Acuto, O, Parton, RG, Gooding, JJ, Rossy, J, Rossjohn, J, Gaus, K
Format: Journal article
Language:English
Published: National Academy of Sciences 2016

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