Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor
Lens epithelium-derived growth factor (LEDGF)/p75 is the dominant binding partner of HIV-1 integrase in human cells. The crystal structure of the HIV integrase-binding domain (IBD) of LEDGF has been determined in the absence of ligand. IBD was overexpressed in Escherichia coli, purified and crystall...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Published: |
International Union of Crystallography
2018
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