Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor

Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor

Lens epithelium-derived growth factor (LEDGF)/p75 is the dominant binding partner of HIV-1 integrase in human cells. The crystal structure of the HIV integrase-binding domain (IBD) of LEDGF has been determined in the absence of ligand. IBD was overexpressed in Escherichia coli, purified and crystall...

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Bibliographic Details
Main Authors:	Hannon, C, Cruz-Migoni, A, Platonova, O, Owen, R, Nettleship, J, Miller, A, Carr, S, Harris, G, Rabbitts, T, Phillips, S
Format:	Journal article
Published:	International Union of Crystallography 2018

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