Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.
Dendritic cells (DCs) are important for presenting antigen to T cells, especially naïve T cells. It has recently been shown that blocking the transcription factor, nuclear factor kappa B (NF-kappaB) in human DCs inhibited the mixed leukocyte reaction. The aim of this study was to investigate the eff...
Main Authors: | Calder, V, Bondeson, J, Brennan, F, Foxwell, B, Feldmann, M |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2003
|
Similar Items
-
Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.
by: Yoshimura, S, et al.
Published: (2001) -
NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
by: Smith, C, et al.
Published: (2001) -
Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
by: Andreakos, E, et al.
Published: (2006) -
Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.
by: Bondeson, J, et al.
Published: (1999) -
Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.
by: Yoshimura, S, et al.
Published: (2003)