DNA gyrase stimulates transcription.

DNA gyrase stimulates transcription.

The nuclear DNA of HeLa cells can now be isolated unbroken and supercoiled. Using DNA gyrase and the untwisting enzyme, we have prepared an allomorphic series of templates derived from this nuclear DNA, and also from the circular DNA of the bacterial virus, PM2. We have then transcribed these templa...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Akrigg, A, Cook, P
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	1980

Eitemau Tebyg

Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase.
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Analysis of pleiotropic transcriptional profiles: a case study of DNA gyrase inhibition.
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DNA Gyrase as a Target for Quinolones
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Rapid, DNA-induced subunit exchange by DNA gyrase
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Rapid, DNA-induced interface swapping by DNA gyrase
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Friend or Foe: Protein Inhibitors of DNA Gyrase
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Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase
gan: Chan, P, et al.
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Electron-microscopy of intact nuclear DNA from human cells.
gan: McCready, S, et al.
Cyhoeddwyd: (1979)

A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor
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Single-molecule imaging of DNA gyrase activity in living Escherichia coli
gan: Stracy, M, et al.
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DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines.
gan: Alexandre Duprey, et al.
Cyhoeddwyd: (2020-10-01)

Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.
gan: Scott S Walker, et al.
Cyhoeddwyd: (2017-01-01)

Comprehensive review of DNA gyrase as enzymatic target for drug discovery and development
gan: K. Rajakumari, et al.
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Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation
gan: Martina Durcik, et al.
Cyhoeddwyd: (2020-12-01)

Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
gan: Jérémie Piton, et al.
Cyhoeddwyd: (2010-01-01)

Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors
gan: Manoj Chandran, et al.
Cyhoeddwyd: (2015-01-01)

The bacteriophage LUZ24 “Igy” peptide inhibits the Pseudomonas DNA gyrase
gan: Jeroen De Smet, et al.
Cyhoeddwyd: (2021-08-01)

In silico analysis of ciprofloxacin analogs as inhibitors of DNA gyrase of Staphylococcus aureus
gan: Md. Rakhibul Hasan, et al.
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Insights into antibacterial design: Computational modeling of eugenol derivatives targeting DNA gyrase
gan: Heba S. Elsewedy, et al.
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Rates of gyrase supercoiling and transcription elongation control supercoil density in a bacterial chromosome.
gan: Nikolay Rovinskiy, et al.
Cyhoeddwyd: (2012-01-01)

Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase
gan: Antoine Gedeon, et al.
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Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology
gan: Alexander Harms, et al.
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Docking studies on novel analogs of quinolones against DNA gyrase of Escherichia coli
gan: Cristian Davila, et al.
Cyhoeddwyd: (2018-09-01)

Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex
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Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores
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Discovery of Novel Inhibitors of Bacterial DNA Gyrase Using a QSAR-Based Approach
gan: Ritu Jakhar, et al.
Cyhoeddwyd: (2022-08-01)

DC-159a Shows Inhibitory Activity against DNA Gyrases of Mycobacterium leprae.
gan: Tomoyuki Yamaguchi, et al.
Cyhoeddwyd: (2016-09-01)

DNA gyrase could be a crucial regulatory factor for growth and survival of Mycobacterium leprae
gan: Hyun Kim, et al.
Cyhoeddwyd: (2019-07-01)

Transformation of a Thermostable G-Quadruplex Structure into DNA Duplex Driven by Reverse Gyrase
gan: Dawei Li, et al.
Cyhoeddwyd: (2017-11-01)

Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
gan: Anja Kolarič, et al.
Cyhoeddwyd: (2021-01-01)

Clinically Relevant Mutant DNA Gyrase Alters Supercoiling, Changes the Transcriptome, and Confers Multidrug Resistance
gan: Mark A. Webber, et al.
Cyhoeddwyd: (2013-08-01)

Application of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VI.
gan: James A Taylor, et al.
Cyhoeddwyd: (2013-01-01)

Synthesis and “In Silico” Evaluation of the Biological Activity of the New Dual Inhibitors of Gyrase DNA and Topoisomerase IV
gan: Lucia Pintilie, et al.
Cyhoeddwyd: (2020-11-01)

An In-Silico Evaluation of Anthraquinones as Potential Inhibitors of DNA Gyrase B of <i>Mycobacterium tuberculosis</i>
gan: Juliana Carolina Amorim, et al.
Cyhoeddwyd: (2022-12-01)

In Vitro Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus
gan: Wassihun Wedajo Aragaw, et al.
Cyhoeddwyd: (2022-02-01)

Impact of amino acid substitutions in B subunit of DNA gyrase in Mycobacterium leprae on fluoroquinolone resistance.
gan: Kazumasa Yokoyama, et al.
Cyhoeddwyd: (2012-01-01)

Alternations in DNA gyrase genes in low-level fluoroquinolone-resistant Moraxella catarrhalis strains isolated in Poland
gan: Król-Turmińska K, et al.
Cyhoeddwyd: (2018-08-01)

Exploration of the novel fluoroquinolones with high inhibitory effect against quinolone-resistant DNA gyrase of Salmonella Typhimurium
gan: Jirachaya Toyting, et al.
Cyhoeddwyd: (2023-12-01)

Experimental and Molecular Docking Studies of Cyclic Diphenyl Phosphonates as DNA Gyrase Inhibitors for Fluoroquinolone-Resistant Pathogens
gan: Neveen M. Saleh, et al.
Cyhoeddwyd: (2022-01-01)

In silico evaluation of usnic acid derivatives to discover potential antibacterial drugs against DNA gyrase B and DNA topoisomerase IV
gan: Miah, Roney, et al.
Cyhoeddwyd: (2023)