Exploring the factors and mechanisms involved in triggering the alternative lengthening of telomeres pathway

<p>Maintaining replicative immortality is a crucial step in the development of cancers and is achieved by activating a telomere lengthening mechanism. While the majority of cancers rely on upregulation of telomerase, approximately 10-15% of cancers achieve telomere length maintenance through...

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Bibliographic Details
Main Author: Kent, T
Other Authors: Gibbons, R
Format: Thesis
Language:English
Published: 2021
Subjects: