Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.

Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.

The Polycomb group of proteins forms at least two distinct complexes designated the Polycomb repressive complex-1 (PRC1) and PRC2. These complexes cooperate to mediate transcriptional repression of their target genes, including the Hox gene cluster and the Cdkn2a genes. Mammalian Polycomb-like gene...

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Bibliographic Details
Main Authors: Li, X, Isono, K, Yamada, D, Endo, T, Endoh, M, Shinga, J, Mizutani-Koseki, Y, Otte, A, Casanova, M, Kitamura, H, Kamijo, T, Sharif, J, Ohara, O, Toyada, T, Bernstein, B, Brockdorff, N, Koseki, H
Format: Journal article
Language:English
Published: 2011

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