Tools for assessing the protective efficacy of TB vaccines in humans: in vitro mycobacterial growth inhibition predicts outcome of in vivo mycobacterial infection

Tuberculosis (TB) remains a leading global cause of morbidity and mortality and an effective new vaccine is urgently needed. A major barrier to the rational development of novel TB vaccines is the lack of a validated immune correlate or biomarker of protection. Mycobacterial Growth Inhibition Assays...

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Bibliographic Details
Main Authors: Tanner, R, Satti, I, Harris, SA, O'Shea, MK, Cizmeci, D, O'Connor, D, Chomka, A, Matsumiya, M, Wittenberg, R, Minassian, AM, Meyer, J, Fletcher, HA, McShane, H
Format: Journal article
Language:English
Published: Frontiers Media 2020