Reduced expression of the growth hormone and type 1 insulin-like growth factor receptors in human somatotroph tumours and an analysis of possible mutations of the growth hormone receptor.

Reduced expression of the growth hormone and type 1 insulin-like growth factor receptors in human somatotroph tumours and an analysis of possible mutations of the growth hormone receptor.

OBJECTIVE: Clinical acromegaly is characterized by elevated GH secretion in the presence of high circulating IGF-I levels. We hypothesized that the physiological IGF-I/GH negative feedback loop may be reset in somatotroph adenomas, specifically in terms of the level of expression of these receptors...

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Bibliographic Details
Main Authors: Kola, B, Korbonits, M, Diaz-Cano, S, Kaltsas, G, Morris, D, Jordan, S, Metherell, L, Powell, M, Czirják, S, Arnaldi, G, Bustin, S, Boscaro, M, Mantero, F, Grossman, AB
Format: Journal article
Language:English
Published: 2003

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