Dimensional analysis of osteoclastic bone resorption and the measurement of biologically active calcitonin.

Calcitonin inhibits bone resorption through a direct action on the osteoclast. We report a quantitative analysis of bone resorption by disaggregated rat osteoclasts. We then used our findings to develop a formal bioassay for calcitonin. Osteoclasts were mechanically disaggregated from neonatal rat l...

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Bibliographic Details
Main Authors: Zaidi, M, Bax, B, Shankar, V, Moonga, B, Simon, B, Alam, A, Gaines Das, R, Pazianas, M, Huang, C
Format: Journal article
Language:English
Published: 1994