Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis.

Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis.

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PURPOSE: Ras/Raf/mitogen-activated protein-extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling is critical for tumor cell proliferation and survival. Selumetinib is a potent, selective, and orally available MEK1/2 inhibitor. In this study, we evaluated the therapeutic efficacy of...

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Bibliographic Details
Main Authors: Takahashi, O, Komaki, R, Smith, P, Jürgensmeier, J, Ryan, A, Bekele, B, Wistuba, I, Jacoby, J, Korshunova, M, Biernacka, A, Erez, B, Hosho, K, Herbst, R, O'Reilly, MS
Format: Journal article
Language:English
Published: 2012

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