Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis.
PURPOSE: Ras/Raf/mitogen-activated protein-extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling is critical for tumor cell proliferation and survival. Selumetinib is a potent, selective, and orally available MEK1/2 inhibitor. In this study, we evaluated the therapeutic efficacy of...
Main Authors: | Takahashi, O, Komaki, R, Smith, P, Jürgensmeier, J, Ryan, A, Bekele, B, Wistuba, I, Jacoby, J, Korshunova, M, Biernacka, A, Erez, B, Hosho, K, Herbst, R, O'Reilly, MS |
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Format: | Journal article |
Language: | English |
Published: |
2012
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