Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila

Alternative mRNA splicing adds a layer of regulation to the expression of thousands of genes in Drosophila melanogaster. Not all alternative splicing results in functional protein; it can also yield mRNA isoforms with premature stop codons that are degraded by the nonsense-mediated mRNA decay (NMD)...

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Bibliographic Details
Main Authors: Hansen, K, Lareau, L, Blanchette, M, Green, R, Meng, Q, Rehwinkel, J, Gallusser, F, Izaurralde, E, Rio, D, Dudoit, S, Brenner, SE
Format: Journal article
Language:English
Published: Public Library of Science 2009