La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

The 5’terminal oligopyrimidine (5’TOP) motif is a cis-regulatory RNA element located immediately downstream of the 7-methylguanosine [m7G] cap of TOP mRNAs, which encode ribosomal proteins and translation factors. In eukaryotes, this motif coordinates the synchronous and stoichiometric expression of...

Full description

Bibliographic Details
Main Authors:	Lahr, RM, Fonseca, BD, Ciotti, GE, Al-Ashtal, HA, Jia, J-J, Niklaus, MR, Blagden, SP, Alain, T, Berman, AJ
Format:	Journal article
Published:	eLife Sciences Publications 2017

Similar Items

Controversies around the function of LARP1
by: Berman, AJ, et al.
Published: (2020)

The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer
by: Hopkins, T, et al.
Published: (2015)

eIF3 engages with 3’-UTR termini of highly translated mRNAs
by: Santi Mestre-Fos, et al.
Published: (2025-01-01)

Water-Bridge Mediates Recognition of mRNA Cap in eIF4E
by: Lama, Dilraj, et al.
Published: (2017)

LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression
by: Blagden, S, et al.
Published: (2015)

mRNA cap-binding protein eIF4E1 is a novel regulator of Toxoplasma gondii latency
by: Michael J. Holmes, et al.
Published: (2024-06-01)

Cellular cap-binding proteins associate with influenza virus mRNAs.
by: Bier, K, et al.
Published: (2011)

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.
by: Behm-Ansmant, I, et al.
Published: (2007)

Changes in NMDA receptor subunit mRNAs and cyclophilin mRNA during development of the human hippocampus.
by: Law, A, et al.
Published: (2003)

Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay.
by: Ponting, C
Published: (2000)

Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1
by: Guennadi Kozlov, et al.
Published: (2024-12-01)

Recycling of Uridylated mRNAs in Starfish Embryos
by: Haruka Yamazaki, et al.
Published: (2024-12-01)

The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs
by: Gangaramani, Paritosh, et al.
Published: (2016)

Transcriptome Sequencing Identifies Abnormal lncRNAs and mRNAs and Reveals Potentially Hub Immune-Related mRNA in Osteoporosis with Vertebral Fracture
by: Sun R, et al.
Published: (2024-02-01)

The RNA-binding protein LARP1 is a cancer therapeutic target
by: Ghazaly, E, et al.
Published: (2017)

Loss of LARP4B, an early event in the tumorigenesis of brain cancer?
by: Blagden, S, et al.
Published: (2016)

Macrophage manufacturing and engineering with 5′-Cap1 and N1-methylpseudouridine-modified mRNA
by: Peixuan Zhang, et al.
Published: (2024-09-01)

IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1
by: Dai, N, et al.
Published: (2017)

IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1
by: Dai, N, et al.
Published: (2017)

Tendon healing induced by chemically modified mRNAs
by: K Groth, et al.
Published: (2017-05-01)

Structured 3′ UTRs destabilize mRNAs in plants
by: Tianru Zhang, et al.
Published: (2024-02-01)

Most mammalian mRNAs are conserved targets of microRNAs
by: Friedman, Robin Carl, et al.
Published: (2011)

LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder
by: James Chettle, et al.
Published: (2024-10-01)

Functional Analysis of GRSF1 in the Nuclear Export and Translation of Influenza A Virus mRNAs
by: Jordana Schmierer, et al.
Published: (2024-07-01)

Telocinobufagin suppresses malignant metastasis of undifferentiated thyroid carcinoma via modulation of the LARP1‐mTOR pathway
by: Li‐Zhi Qiang, et al.
Published: (2025-03-01)

Integrated analysis of miRNAs and mRNAs in thousands of single cells
by: Jia Li, et al.
Published: (2025-01-01)

Simultaneous expansion microscopy imaging of proteins and mRNAs via dual-ExM
by: In Cho, et al.
Published: (2022-03-01)

CleanCap M6 inhibits decapping of exogenously delivered IVT mRNA
by: Zachary F. Mandell, et al.
Published: (2025-03-01)

FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression
by: Faiz Ali Khan, et al.
Published: (2024-11-01)

Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5
by: Eiji Obayashi, et al.
Published: (2024-06-01)

The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein
by: Robb, N, et al.
Published: (2012)

The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein.
by: Robb, N, et al.
Published: (2012)

A KIF1C-CNBP motor-adaptor complex for trafficking mRNAs to cell protrusions
by: Konstadinos Moissoglu, et al.
Published: (2025-03-01)

Comparative analysis of the LARP1 C-terminal DM15 region through Coelomate evolution
by: Elaine Nguyen, et al.
Published: (2024-01-01)

MicroRNAs Cause Accelerated Decay of Short-Tailed Target mRNAs
by: Eisen, Timothy J, et al.
Published: (2021)

MicroRNAs Cause Accelerated Decay of Short-Tailed Target mRNAs
by: Eisen, Timothy Jonas, et al.
Published: (2022)

Integrative transcriptomic profiling of ncRNAs and mRNAs in developing mouse lens
by: Liyun Zhang, et al.
Published: (2024-06-01)

Dynamic patterning of maternal mRNAs in the Early C. elegans embryo
by: Li, Jialing, Ph. D. Massachusetts Institute of Technology
Published: (2013)

Distal Alternative Last Exons Localize mRNAs to Neural Projections
by: Vidaki, Marina, et al.
Published: (2018)

Reconsidering Movement of Eukaryotic mRNAs between Polysomes and P Bodies
by: Doudna, Jennifer A., et al.
Published: (2014)