La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

The 5’terminal oligopyrimidine (5’TOP) motif is a cis-regulatory RNA element located immediately downstream of the 7-methylguanosine [m7G] cap of TOP mRNAs, which encode ribosomal proteins and translation factors. In eukaryotes, this motif coordinates the synchronous and stoichiometric expression of...

Full description

Bibliographic Details
Main Authors:	Lahr, RM, Fonseca, BD, Ciotti, GE, Al-Ashtal, HA, Jia, J-J, Niklaus, MR, Blagden, SP, Alain, T, Berman, AJ
Format:	Journal article
Published:	eLife Sciences Publications 2017

Similar Items

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs
by: Roni M Lahr, et al.
Published: (2017-04-01)

Controversies around the function of LARP1
by: Berman, AJ, et al.
Published: (2020)

The LARP1 homolog Slr1p controls the stability and expression of proto-5′TOP mRNAs in fission yeast
by: Farnaz Mansouri-Noori, et al.
Published: (2023-10-01)

LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
by: Sungki Hong, et al.
Published: (2017-06-01)

The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer
by: Hopkins, T, et al.
Published: (2015)

eIF3 Interacts with Selenoprotein mRNAs
by: Hassan Hayek, et al.
Published: (2022-09-01)

LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression
by: Blagden, S, et al.
Published: (2015)

eIF3 engages with 3’-UTR termini of highly translated mRNAs
by: Santi Mestre-Fos, et al.
Published: (2025-01-01)

LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection
by: Sandy Mattijssen, et al.
Published: (2017-09-01)

eIF3 and Its mRNA-Entry-Channel Arm Contribute to the Recruitment of mRNAs With Long 5′-Untranslated Regions
by: Andrei Stanciu, et al.
Published: (2022-01-01)

Water-Bridge Mediates Recognition of mRNA Cap in eIF4E
by: Lama, Dilraj, et al.
Published: (2017)

Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity
by: Paul Yourik, et al.
Published: (2017-11-01)

Corrigendum: eIF3 and Its mRNA-Entry-Channel Arm Contribute to the Recruitment of mRNAs With Long 5′-Untranslated Regions
by: Andrei Stanciu, et al.
Published: (2022-04-01)

Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1
by: Guennadi Kozlov, et al.
Published: (2024-12-01)

Loss of LARP4B, an early event in the tumorigenesis of brain cancer?
by: Blagden, S, et al.
Published: (2016)

MicroRNAs recruit eIF4E2 to repress translation of target mRNAs
by: Shaohong Chen, et al.
Published: (2017-07-01)

mRNA cap-binding protein eIF4E1 is a novel regulator of Toxoplasma gondii latency
by: Michael J. Holmes, et al.
Published: (2024-06-01)

The RNA-binding protein LARP1 is a cancer therapeutic target
by: Ghazaly, E, et al.
Published: (2017)

Cellular cap-binding proteins associate with influenza virus mRNAs.
by: Bier, K, et al.
Published: (2011)

The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5′ and 3′ Termini of Target mRNAs
by: Tamiko Nishimura, et al.
Published: (2015-06-01)

The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
by: Marina P Volegova, et al.
Published: (2023-01-01)

The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs
by: Marina P. Volegova, et al.
Published: (2023-01-01)

Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference.
by: Arti N Santhanam, et al.
Published: (2009-01-01)

LARP1 haploinsufficiency is associated with an autosomal dominant neurodevelopmental disorder
by: James Chettle, et al.
Published: (2024-10-01)

Glucose controls co-translation of structurally related mRNAs via the mTOR and eIF2 pathways in human pancreatic beta cells
by: Manuel Bulfoni, et al.
Published: (2022-08-01)

Telocinobufagin suppresses malignant metastasis of undifferentiated thyroid carcinoma via modulation of the LARP1‐mTOR pathway
by: Li‐Zhi Qiang, et al.
Published: (2025-03-01)

Correction: Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference
Published: (2009-01-01)

Correction: Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference.
by: Arti N. Santhanam, et al.
Published: (2009-01-01)

The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci
by: Anand K Singh, et al.
Published: (2019-03-01)

The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence
by: Lahr, R, et al.
Published: (2015)

A Novel Strategy for Regulating mRNA’s Degradation via Interfering the AUF1’s Binding to mRNA
by: Kun-Tao Li, et al.
Published: (2022-05-01)

Comparative analysis of the LARP1 C-terminal DM15 region through Coelomate evolution
by: Elaine Nguyen, et al.
Published: (2024-01-01)

XRN4 and LARP1 Are Required for a Heat-Triggered mRNA Decay Pathway Involved in Plant Acclimation and Survival during Thermal Stress
by: Rémy Merret, et al.
Published: (2013-12-01)

The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif
by: Grishin Nick V, et al.
Published: (2009-01-01)

SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage.
by: Cheng Huang, et al.
Published: (2011-12-01)

Elucidating the functional role and therapeutic potential of La-related protein 1B (LARP1B) in cancer and its interplay with other LARP family members
by: Nawaz, A
Published: (2023)

Trafficking and localization of KNOTTED1 related mRNAs in shoot meristems
by: Munenori Kitagawa, et al.
Published: (2022-12-01)

Data on the stability of Prx1-associated snRNAs and mRNAs
by: Eun-Kyung Kim, et al.
Published: (2019-08-01)

Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway
by: Zhiyun Ge, et al.
Published: (2016-01-01)

Genome-wide investigation of the LARP gene family: focus on functional identification and transcriptome profiling of ZmLARP6c1 in maize pollen
by: Xiaoqin Xiang, et al.
Published: (2024-04-01)