The Ii41 isoform of invariant chain mediates both positive and negative selection events in T-cell receptor transgenic mice.
The functional role of invariant chain in T-cell selection events and antigen presentation is well established. The invariant chain gene encodes differentially spliced isoforms, Ii31 and Ii41. The Ii41 isoform has been described to increase the efficiency of antigen presentation. We have analysed th...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1998
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