PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions
Proliferating cell nuclear antigen (PCNA) is an essential cofactor for DNA replication and repair, recruiting multiple proteins to their sites of action. We examined the effects of the PCNA S228I mutation that causes PCNA-associated DNA repair disorder (PARD). Cells from individuals affected by PAR...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2016
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