Delay in onset of insulitis in NOD mice following a single injection of CD 4 and CD 8 antibodies.

Non-obese diabetic (NOD) mice injected with 500 micrograms of both CD 4 and CD 8 antibodies at 5 weeks of age did not develop insulitis until 18 weeks of age, 12 weeks later than the onset of insulitis in parallel uninjected controls. Injection with both antibodies at 2 weeks or 4 weeks of age prote...

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Bibliographic Details
Main Authors: Hayward, A, Cobbold, S, Waldmann, H, Cooke, A, Simpson, E
Format: Journal article
Language:English
Published: 1988