Human stem cell models of neurodegeneration: from basic science of amyotrophic lateral sclerosis to clinical translation

Neurodegenerative diseases are characterized by progressive cell loss leading to disruption of the structure and function of the central nervous system. Amyotrophic lateral sclerosis (ALS) was among the first of these disorders modeled in patient-specific iPSCs, and recent findings have translated i...

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Bibliographic Details
Main Authors: Giacomelli, E, Vahsen, BF, Calder, EL, Xu, Y, Scaber, J, Gray, E, Dafinca, R, Talbot, K, Studer, L
Format: Journal article
Language:English
Published: Cell Press 2022