Non-invasive assessment of metformin induced changes in cardiac and hepatic redox state using hyperpolarized [1–13C] pyruvate
Metformin’s mechanism of action is controversial though may involve suppression of hepatic gluconeogenesis through perturbation of cellular redox state. Hyperpolarized magnetic resonance with [1-13C] pyruvate exploits huge increases in tracer signal to non-invasively assess both the redox coupled la...
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BMJ Publishing Group
2016
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