E. coli Nickel-Iron Hydrogenase 1 catalyses non-native reduction of flavins: demonstration for alkene hydrogenation by old yellow enzyme ene-reductases

A new activity for the [NiFe] uptake hydrogenase 1 of Escherichia coli (Hyd1) is presented. Direct reduction of biological flavin cofactors FMN and FAD is achieved using H2 as a simple, completely atom-economical reductant. The robust nature of Hyd1 is exploited for flavin reduction across a broad r...

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Detalhes bibliográficos
Principais autores: Joseph Srinivasan, S, Cleary, S, Ramirez Hernandez, M, Reeve, H, Vincent, K
Formato: Journal article
Idioma:English
Publicado em: Wiley 2021