Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.

Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension.

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Heparan and chondroitin sulfate proteoglycans (HSPGs and CSPGs, respectively) regulate numerous cell surface signaling events, with typically opposite effects on cell function. CSPGs inhibit nerve regeneration through receptor protein tyrosine phosphatase sigma (RPTPσ). Here we report that RPTPσ act...

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Bibliographic Details
Main Authors: Coles, C, Shen, Y, Tenney, A, Siebold, C, Sutton, G, Lu, W, Gallagher, J, Jones, E, Flanagan, J, Aricescu, A
Format: Journal article
Language:English
Published: 2011

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