SOME SUBSTITUTION-REACTIONS OF LIGANDS COORDINATED TO THE BIS(CYCLOPENTADIENYL)TITANIUM MOIETY, THE X-RAY CRYSTAL-STRUCTURE OF TI(ETA-5-C5H5)2(OPH)2 AND AN ASSESSMENT OF THE ANTITUMOR-ACTIVITY OF SOME CYCLOPENTADIENYL TITANIUM COMPOUNDS
The new complexes Ti(η5-C5H5)Cl(OC6H4NH2-3)2, Ti(η5-C5H5)Cl(O2CPh)2, Ti(η5-C5H5)2(O2C(S)C6H4-1,2), Ti(η5-C5H5)2Cl(SC6H4OH-4), Ti(η5-C5H5)2(OC6H4NH2-3)2 and Ti(η5-C5H5)2Cl(OC6H4Z) (Z = NO2-2, NO2-3, NO2-4, NH2-3) have been synthesized. The free amine group in Ti(η5-C5H5)2Cl(OC6H4NH2-3) reacts with RC...
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Journal article |
| Veröffentlicht: |
1991
|
| _version_ | 1826259803512504320 |
|---|---|
| author | Kalirai, B Foulon, J Hamor, T Jones, C Beer, P Fricker, S |
| author_facet | Kalirai, B Foulon, J Hamor, T Jones, C Beer, P Fricker, S |
| author_sort | Kalirai, B |
| collection | OXFORD |
| description | The new complexes Ti(η5-C5H5)Cl(OC6H4NH2-3)2, Ti(η5-C5H5)Cl(O2CPh)2, Ti(η5-C5H5)2(O2C(S)C6H4-1,2), Ti(η5-C5H5)2Cl(SC6H4OH-4), Ti(η5-C5H5)2(OC6H4NH2-3)2 and Ti(η5-C5H5)2Cl(OC6H4Z) (Z = NO2-2, NO2-3, NO2-4, NH2-3) have been synthesized. The free amine group in Ti(η5-C5H5)2Cl(OC6H4NH2-3) reacts with RCl [R = MeCO, PhCO, (OCCO)1/2, Br(CH2)3CO] in the presence of base to give Ti(η5-C5H5)2Cl(R) but, in the absence of base, PhCOCl reacts to give PhCONHC6H4OH-3 and Ti(η5-C5H5)2Cl2. The X-ray crystal structure of Ti(η5-C5H5)2(OPh)2 has been determined and reveals a pseudo-tetrahedral arrangement of the two η5-cyclopentadienyl and two phenoxide ligands around titanium. The Ti-O(Ph) distances are 1.907(3) Å and O-Ti-O is 98.1(2)°. The anti-tumour activities of Ti(η5-C5H5)Cl(OC6H4NH2-3)2, Ti(η5-C5H5)Cl(O2CPh)2 and Ti(η5-C5H5)2(O2C(S)C6H4-1,2) have been assessed in vitro using a panel of seven human tumour cell lines. © 1991. |
| first_indexed | 2024-03-06T18:55:34Z |
| format | Journal article |
| id | oxford-uuid:11b5c7b3-d985-45bc-a3bd-d6b6d34c9fb8 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:55:34Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:11b5c7b3-d985-45bc-a3bd-d6b6d34c9fb82022-03-26T10:03:48ZSOME SUBSTITUTION-REACTIONS OF LIGANDS COORDINATED TO THE BIS(CYCLOPENTADIENYL)TITANIUM MOIETY, THE X-RAY CRYSTAL-STRUCTURE OF TI(ETA-5-C5H5)2(OPH)2 AND AN ASSESSMENT OF THE ANTITUMOR-ACTIVITY OF SOME CYCLOPENTADIENYL TITANIUM COMPOUNDSJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:11b5c7b3-d985-45bc-a3bd-d6b6d34c9fb8Symplectic Elements at Oxford1991Kalirai, BFoulon, JHamor, TJones, CBeer, PFricker, SThe new complexes Ti(η5-C5H5)Cl(OC6H4NH2-3)2, Ti(η5-C5H5)Cl(O2CPh)2, Ti(η5-C5H5)2(O2C(S)C6H4-1,2), Ti(η5-C5H5)2Cl(SC6H4OH-4), Ti(η5-C5H5)2(OC6H4NH2-3)2 and Ti(η5-C5H5)2Cl(OC6H4Z) (Z = NO2-2, NO2-3, NO2-4, NH2-3) have been synthesized. The free amine group in Ti(η5-C5H5)2Cl(OC6H4NH2-3) reacts with RCl [R = MeCO, PhCO, (OCCO)1/2, Br(CH2)3CO] in the presence of base to give Ti(η5-C5H5)2Cl(R) but, in the absence of base, PhCOCl reacts to give PhCONHC6H4OH-3 and Ti(η5-C5H5)2Cl2. The X-ray crystal structure of Ti(η5-C5H5)2(OPh)2 has been determined and reveals a pseudo-tetrahedral arrangement of the two η5-cyclopentadienyl and two phenoxide ligands around titanium. The Ti-O(Ph) distances are 1.907(3) Å and O-Ti-O is 98.1(2)°. The anti-tumour activities of Ti(η5-C5H5)Cl(OC6H4NH2-3)2, Ti(η5-C5H5)Cl(O2CPh)2 and Ti(η5-C5H5)2(O2C(S)C6H4-1,2) have been assessed in vitro using a panel of seven human tumour cell lines. © 1991. |
| spellingShingle | Kalirai, B Foulon, J Hamor, T Jones, C Beer, P Fricker, S SOME SUBSTITUTION-REACTIONS OF LIGANDS COORDINATED TO THE BIS(CYCLOPENTADIENYL)TITANIUM MOIETY, THE X-RAY CRYSTAL-STRUCTURE OF TI(ETA-5-C5H5)2(OPH)2 AND AN ASSESSMENT OF THE ANTITUMOR-ACTIVITY OF SOME CYCLOPENTADIENYL TITANIUM COMPOUNDS |
| title | SOME SUBSTITUTION-REACTIONS OF LIGANDS COORDINATED TO THE BIS(CYCLOPENTADIENYL)TITANIUM MOIETY, THE X-RAY CRYSTAL-STRUCTURE OF TI(ETA-5-C5H5)2(OPH)2 AND AN ASSESSMENT OF THE ANTITUMOR-ACTIVITY OF SOME CYCLOPENTADIENYL TITANIUM COMPOUNDS |
| title_full | SOME SUBSTITUTION-REACTIONS OF LIGANDS COORDINATED TO THE BIS(CYCLOPENTADIENYL)TITANIUM MOIETY, THE X-RAY CRYSTAL-STRUCTURE OF TI(ETA-5-C5H5)2(OPH)2 AND AN ASSESSMENT OF THE ANTITUMOR-ACTIVITY OF SOME CYCLOPENTADIENYL TITANIUM COMPOUNDS |
| title_fullStr | SOME SUBSTITUTION-REACTIONS OF LIGANDS COORDINATED TO THE BIS(CYCLOPENTADIENYL)TITANIUM MOIETY, THE X-RAY CRYSTAL-STRUCTURE OF TI(ETA-5-C5H5)2(OPH)2 AND AN ASSESSMENT OF THE ANTITUMOR-ACTIVITY OF SOME CYCLOPENTADIENYL TITANIUM COMPOUNDS |
| title_full_unstemmed | SOME SUBSTITUTION-REACTIONS OF LIGANDS COORDINATED TO THE BIS(CYCLOPENTADIENYL)TITANIUM MOIETY, THE X-RAY CRYSTAL-STRUCTURE OF TI(ETA-5-C5H5)2(OPH)2 AND AN ASSESSMENT OF THE ANTITUMOR-ACTIVITY OF SOME CYCLOPENTADIENYL TITANIUM COMPOUNDS |
| title_short | SOME SUBSTITUTION-REACTIONS OF LIGANDS COORDINATED TO THE BIS(CYCLOPENTADIENYL)TITANIUM MOIETY, THE X-RAY CRYSTAL-STRUCTURE OF TI(ETA-5-C5H5)2(OPH)2 AND AN ASSESSMENT OF THE ANTITUMOR-ACTIVITY OF SOME CYCLOPENTADIENYL TITANIUM COMPOUNDS |
| title_sort | some substitution reactions of ligands coordinated to the bis cyclopentadienyl titanium moiety the x ray crystal structure of ti eta 5 c5h5 2 oph 2 and an assessment of the antitumor activity of some cyclopentadienyl titanium compounds |
| work_keys_str_mv | AT kaliraib somesubstitutionreactionsofligandscoordinatedtothebiscyclopentadienyltitaniummoietythexraycrystalstructureoftieta5c5h52oph2andanassessmentoftheantitumoractivityofsomecyclopentadienyltitaniumcompounds AT foulonj somesubstitutionreactionsofligandscoordinatedtothebiscyclopentadienyltitaniummoietythexraycrystalstructureoftieta5c5h52oph2andanassessmentoftheantitumoractivityofsomecyclopentadienyltitaniumcompounds AT hamort somesubstitutionreactionsofligandscoordinatedtothebiscyclopentadienyltitaniummoietythexraycrystalstructureoftieta5c5h52oph2andanassessmentoftheantitumoractivityofsomecyclopentadienyltitaniumcompounds AT jonesc somesubstitutionreactionsofligandscoordinatedtothebiscyclopentadienyltitaniummoietythexraycrystalstructureoftieta5c5h52oph2andanassessmentoftheantitumoractivityofsomecyclopentadienyltitaniumcompounds AT beerp somesubstitutionreactionsofligandscoordinatedtothebiscyclopentadienyltitaniummoietythexraycrystalstructureoftieta5c5h52oph2andanassessmentoftheantitumoractivityofsomecyclopentadienyltitaniumcompounds AT frickers somesubstitutionreactionsofligandscoordinatedtothebiscyclopentadienyltitaniummoietythexraycrystalstructureoftieta5c5h52oph2andanassessmentoftheantitumoractivityofsomecyclopentadienyltitaniumcompounds |