Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart.

Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart.

The CAMPATH-1 family of antibodies are able systematically to lyse human lymphocytes with human complement by targeting the small cell-surface glycoprotein CD52, commonly called the CAMPATH-1 antigen. These antibodies have been used clinically for several years, providing therapy for patients with a...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Cheetham, G, Hale, G, Waldmann, H, Bloomer, A
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	1998

Antzeko izenburuak

1.9 A structure of the therapeutic antibody CAMPATH-1H fab in complex with a synthetic peptide antigen.
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The CAMPATH-1 antigen (CDw52).
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Impact on T-cell depletion and CD34+ cell recovery using humanised CD52 monoclonal antibody (CAMPATH-1H) in BM and PSBC collections; comparison with CAMPATH-1M and CAMPATH-1G.
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Anti-globulin responses to rat and humanized CAMPATH-1 monoclonal antibody used to treat transplant rejection.
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Rat monoclonal antibodies for bone marrow transplantation--the CAMPATH series.
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Specificity of monoclonal antibody Campath-1.
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RAT MONOCLONAL-ANTIBODIES FOR BONE-MARROW TRANSPLANTATION (BMT) - THE CAMPATH SERIES
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Peripheral blood dendritic cells express CD52 and are depleted in-vivo by treatment with CAMPATH-1H.
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Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen.
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Availability of Campath-1 antibodies for bone marrow transplantation.
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CAMPATH-1 monoclonal antibodies in bone marrow transplantation.
nork: Hale, G, et al.
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Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL).
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EFFECTS OF MONOCLONAL-ANTIBODIES OF THE CAMPATH SERIES INVIVO - REQUIREMENTS FOR EFFECTIVE ANTIBODY THERAPY
nork: Dyer, M, et al.
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ISOTYPE VARIANTS OF CAMPATH-1 ANTIBODY - REQUIREMENTS FOR EFFECTIVE ANTIBODY ACTION INVIVO
nork: Dyer, M, et al.
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Recent results using CAMPATH-1 antibodies to control GVHD and graft rejection.
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Pilot study of CAMPATH-1, a rat monoclonal antibody that fixes human complement, as an immunosuppressant in organ transplantation.
nork: Hale, G, et al.
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Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype.
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Autografting with CD52 monoclonal antibody-purged marrow for acute lymphoblastic leukemia.
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CAMPATH-1 antibodies in stem-cell transplantation.
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Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H.
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CAMPATH: from concept to clinic.
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Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1).
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Reactivity of rat monoclonal antibody CAMPATH-1 with human leukaemia cells and its possible application for autologous bone marrow transplantation.
nork: Hale, G, et al.
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TREATMENT OF RHEUMATOID-ARTHRITIS WITH HUMANIZED ANTILYMPHOCYTE ANTIBODY CAMPATH-1H
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CAMPATH-1 monoclonal antibody therapy in severe refractory autoimmune thrombocytopenic purpura.
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Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes.
nork: Hale, G, et al.
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Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone.
nork: Xia, M, et al.
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Autologous transplantation with CD52 monoclonal antibody-purged marrow for acute lymphoblastic leukemia.
nork: Singhal, S, et al.
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Converting monoclonal antibodies into Fab fragments for transient expression in mammalian cells.
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Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H.
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REMISSION INDUCTION IN PATIENTS WITH LYMPHOID MALIGNANCIES USING UNCONJUGATED CAMPATH-1 MONOCLONAL-ANTIBODIES
nork: Dyer, M, et al.
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A personal history of the CAMPATH-1H antibody.
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Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H: effects on complement lysis.
nork: Greenwood, J, et al.
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COMPLEMENT LYSIS MEDIATED BY ENGINEERED MULTIPLE-DOMAIN FORMS OF THE THERAPEUTIC ANTIBODY CAMPATH-1H
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Engraftment of marrow allografts treated with Campath-1 monoclonal antibodies.
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Reversal of allograft rejection using the monoclonal antibody, Campath-1G.
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In vivo/ex vivo T-cell depletion with anti-CD52 monoclonal antibodies: long-term results in patients with acute leukaemia in CR1
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Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance.
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Monoclonal antibody therapy of chronic intraocular inflammation using Campath-1H.
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Reshaping a therapeutic CD4 antibody.
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