Replicative DNA polymerase mutations in cancer.
Three DNA polymerases - Pol α, Pol δ and Pol ɛ - are essential for DNA replication. After initiation of DNA synthesis by Pol α, Pol δ or Pol ɛ take over on the lagging and leading strand respectively. Pol δ and Pol ɛ perform the bulk of replication with very high fidelity, which is ensured by Watson...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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