Replicative DNA polymerase mutations in cancer.

Replicative DNA polymerase mutations in cancer.

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Three DNA polymerases - Pol α, Pol δ and Pol ɛ - are essential for DNA replication. After initiation of DNA synthesis by Pol α, Pol δ or Pol ɛ take over on the lagging and leading strand respectively. Pol δ and Pol ɛ perform the bulk of replication with very high fidelity, which is ensured by Watson...

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Bibliographic Details
Main Authors:	Heitzer, E, Tomlinson, I
Format:	Journal article
Language:	English
Published:	2014

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