Replicative DNA polymerase mutations in cancer.

Three DNA polymerases - Pol α, Pol δ and Pol ɛ - are essential for DNA replication. After initiation of DNA synthesis by Pol α, Pol δ or Pol ɛ take over on the lagging and leading strand respectively. Pol δ and Pol ɛ perform the bulk of replication with very high fidelity, which is ensured by Watson...

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मुख्य लेखकों: Heitzer, E, Tomlinson, I
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2014
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Replicative DNA polymerase mutations in cancer द्वारा Heitzer, E, Tomlinson, I

प्रकाशित 2014
Journal article