Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution.
1 In eighteen subjects receiving digoxin therapy the apparent volume of distribution (Vd) of the drug has been calculated. 2 For each subject the sensitivity of the 86Rb transport mechanism of his pre-treatment erythrocytes to in vitro inhibition by digoxin has been measured (IC50). 3 The Vd of digo...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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1977
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| _version_ | 1797054383561637888 |
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| author | Aronson, J Grahame-Smith, D |
| author_facet | Aronson, J Grahame-Smith, D |
| author_sort | Aronson, J |
| collection | OXFORD |
| description | 1 In eighteen subjects receiving digoxin therapy the apparent volume of distribution (Vd) of the drug has been calculated. 2 For each subject the sensitivity of the 86Rb transport mechanism of his pre-treatment erythrocytes to in vitro inhibition by digoxin has been measured (IC50). 3 The Vd of digoxin correlates both with the age of the patients and with the IC50 of their pre-treatment erythrocytes. 4 The implications of these findings are discussed in terms of the possible determinants of the Vd of digoxin. 5 Digoxin requirements may be predictable before therapy commences if IC50 measurements are performed. |
| first_indexed | 2024-03-06T18:56:31Z |
| format | Journal article |
| id | oxford-uuid:12056533-eb02-4388-ab53-d63a1da4acd9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:56:31Z |
| publishDate | 1977 |
| record_format | dspace |
| spelling | oxford-uuid:12056533-eb02-4388-ab53-d63a1da4acd92022-03-26T10:05:36ZMonitoring digoxin therapy: II. Determinants of the apparent volume of distribution.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:12056533-eb02-4388-ab53-d63a1da4acd9EnglishSymplectic Elements at Oxford1977Aronson, JGrahame-Smith, D1 In eighteen subjects receiving digoxin therapy the apparent volume of distribution (Vd) of the drug has been calculated. 2 For each subject the sensitivity of the 86Rb transport mechanism of his pre-treatment erythrocytes to in vitro inhibition by digoxin has been measured (IC50). 3 The Vd of digoxin correlates both with the age of the patients and with the IC50 of their pre-treatment erythrocytes. 4 The implications of these findings are discussed in terms of the possible determinants of the Vd of digoxin. 5 Digoxin requirements may be predictable before therapy commences if IC50 measurements are performed. |
| spellingShingle | Aronson, J Grahame-Smith, D Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution. |
| title | Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution. |
| title_full | Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution. |
| title_fullStr | Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution. |
| title_full_unstemmed | Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution. |
| title_short | Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution. |
| title_sort | monitoring digoxin therapy ii determinants of the apparent volume of distribution |
| work_keys_str_mv | AT aronsonj monitoringdigoxintherapyiideterminantsoftheapparentvolumeofdistribution AT grahamesmithd monitoringdigoxintherapyiideterminantsoftheapparentvolumeofdistribution |