Continuous base identification for single-molecule nanopore DNA sequencing

A single-molecule method for sequencing DNA that does not require fluorescent labelling could reduce costs and increase sequencing speeds. An exonuclease enzyme might be used to cleave individual nucleotide molecules from the DNA, and when coupled to an appropriate detection system, these nucleotide...

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Bibliographic Details
Main Authors: Clarke, J, Wu, H, Jayasinghe, L, Patel, A, Reid, S, Bayley, H
Format: Journal article
Language:English
Published: Macmillan Publishers Ltd. 2009
Subjects: