Modular synthesis of di- and trisubstituted imidazoles from ketones and aldehydes: a route to kinase inhibitors

A one-pot and modular approach to the synthesis of 2,4(5)-disubstituted imidazoles was developed based on ketone oxidation, employing catalytic HBr and DMSO, followed by imidazole condensation with aldehydes. This methodology afforded twenty-nine disubstituted NH-imidazoles (23%–85% yield). A three-...

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Bibliographic Details
Main Authors: De Toledo, I, Grigolo, TA, Bennett, JM, Elkins, J, Pilli, RA
Format: Journal article
Language:English
Published: American Chemical Society 2019