A meta-research study revealed several challenges in obtaining placebos for investigator-initiated drug trials

A meta-research study revealed several challenges in obtaining placebos for investigator-initiated drug trials

<p><strong>Objectives:</strong><br /> To systematically assess the kind of placebos used in investigator-initiated randomized controlled trials (RCTs), from where they are obtained, and the hurdles that exist in obtaining them.</p><br /> <p><strong>St...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Speich, B, Logullo, P, Deuster, S, Marian, IR, Moschandreas, J, Herav, AT, Gloy, V, Briel, M, Hopewell, S
Tác giả khác:	MAking Randomised Trials Affordable (MARTA) Group
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Elsevier 2020

Những quyển sách tương tự

Reliability of trial information across registries for trials with multiple registrations: a systematic review
Bằng: Speich, B, et al.
Được phát hành: (2021)

Reporting quality of journal abstracts for surgical randomized controlled trials before and after the implementation of the CONSORT extension for abstracts
Bằng: Speich, B, et al.
Được phát hành: (2019)

Comparison of randomized controlled trials discontinued or revised for poor recruitment and completed trials with the same research question: a matched qualitative study
Bằng: Briel, M, et al.
Được phát hành: (2019)

Comparison of randomized controlled trials discontinued or revised for poor recruitment and completed trials with the same research question: a matched qualitative study
Bằng: Matthias Briel, et al.
Được phát hành: (2019-12-01)

A scoping review shows that several nonvalidated budget planning tools for randomized trials are available
Bằng: Speich, B, et al.
Được phát hành: (2019)

Investigational medicinal products, related costs and hospital pharmacy services for investigator-initiated trials: A mixed-methods study.
Bằng: Ala Taji Heravi, et al.
Được phát hành: (2022-01-01)

What proportion of ethically approved randomised clinical trials can be found in a trial registry?
Bằng: Speich, B, et al.
Được phát hành: (2019)

Initial Severity of Schizophrenia and Efficacy of Antipsychotics: Participant-Level Meta-analysis of 6 Placebo-Controlled Studies.
Bằng: Furukawa, T, et al.
Được phát hành: (2015)

Obtaining and managing data sets for individual participant data meta-analysis: scoping review and practical guide
Bằng: Matthew Ventresca, et al.
Được phát hành: (2020-05-01)

Methods for obtaining unpublished data.
Bằng: Young, T, et al.
Được phát hành: (2011)

Obstructive Sleep Apnea
Bằng: R. Rashed, et al.
Được phát hành: (2006-03-01)

Impact of a short version of the CONSORT checklist for peer reviewers to improve the reporting of randomised controlled trials published in biomedical journals: study protocol for a randomised controlled trial
Bằng: Matthias Briel, et al.
Được phát hành: (2020-03-01)

Single-dose versus 3-day cotrimoxazole prophylaxis in transurethral resection or greenlight laser vaporisation of the prostate: study protocol for a multicentre randomised placebo controlled non-inferiority trial (CITrUS trial)
Bằng: Speich, B, et al.
Được phát hành: (2019)

60 years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Meta-regression of predictors of placebo response
Bằng: Leucht, S, et al.
Được phát hành: (2018)

Reslizumab versus placebo for poorly controlled, severe eosinophilic asthma: Meta-analysis
Bằng: Milosavljević Miloš N., et al.
Được phát hành: (2018-01-01)

Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration.
Bằng: Irving Kirsch, et al.
Được phát hành: (2008-02-01)

Scoping review and characteristics of publicly available checklists for assessing clinical trial feasibility
Bằng: Viktoria Gloy, et al.
Được phát hành: (2022-05-01)

Impact of a short version of the CONSORT checklist for peer reviewers to improve the reporting of randomised controlled trials published in biomedical journals: study protocol for a randomised controlled trial
Bằng: Speich, B, et al.
Được phát hành: (2020)

A meta-analysis of the placebo response in antimuscarinic drug trials for overactive bladder
Bằng: Creanga Dana, et al.
Được phát hành: (2009-07-01)

Initial symptom severity of bipolar I disorder and the efficacy of olanzapine: a meta-analysis of individual participant data from five placebo-controlled studies
Bằng: Samara, MT, et al.
Được phát hành: (2017)

Impact of prior dengue infection on severity and outcomes: meta-analysis of placebo-controlled trials
Bằng: Alejandro Macchia, et al.
Được phát hành: (2024-12-01)

Towards full clinical trial registration and results publication: longitudinal meta-research study in Northwestern and Central Switzerland
Bằng: Katharina Klatte, et al.
Được phát hành: (2023-01-01)

Design and rationale for an empirical investigation of the resource use and costs of investigator-initiated randomized trials in Switzerland, the UK, and Germany
Bằng: Alexandra Griessbach, et al.
Được phát hành: (2024-10-01)

Single-dose versus 3-day cotrimoxazole prophylaxis in transurethral resection or greenlight laser vaporisation of the prostate: study protocol for a multicentre randomised placebo controlled non-inferiority trial (CITrUS trial)
Bằng: Benjamin Speich, et al.
Được phát hành: (2019-02-01)

Disconnection of drug-response and placebo-response in acute-phase antipsychotic drug trials on schizophrenia? Meta-regression analysis
Bằng: Leucht, S, et al.
Được phát hành: (2019)

Description of the relationship between NOHL classification in drug-induced sleep endoscopy and initial AHI in patients with moderate to severe OSAS, and evaluation of the results obtained with oral appliance therapy
Bằng: Claudio Vicini, et al.
Được phát hành: (2020-02-01)

An efficient framework for obtaining the initial cluster centers
Bằng: B. K. Mishra, et al.
Được phát hành: (2023-11-01)

Drugs obtained by biotechnology processing
Bằng: Hugo Almeida, et al.
Được phát hành: (2011-06-01)

The Two Sides of Placebo Analgesia: Differential Functional Connectivity Reveals Mechanisms of Placebo Analgesic Response
Bằng: Bush NJ, et al.
Được phát hành: (2025-01-01)

Drug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design
Bằng: Muhammad M. Hammami, et al.
Được phát hành: (2016-11-01)

TIDieR-Placebo: a guide and checklist for reporting placebo and sham controls
Bằng: Howick, J, et al.
Được phát hành: (2020)

Interaction between drug and placebo effects: a cross-over balanced placebo design trial
Bằng: Alvi Syed, et al.
Được phát hành: (2010-11-01)

Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: Systematic review, Bayesian meta-analysis, and meta-regression of efficacy predictors.
Bằng: Leucht, S, et al.
Được phát hành: (2017)

Sixty years of placebo-controlled antipsychotic drug trials in acute schizophrenia: systematic review, Bayesian meta-analysis, and meta-regression of efficacy predictors
Bằng: Leucht, S, et al.
Được phát hành: (2017)

Safety and efficacy of tezepelumab vs. placebo in adult patients with severe uncontrolled asthma: a systematic review and meta-analysis
Bằng: Mahmoud Shaban Abdelgalil, et al.
Được phát hành: (2022-12-01)

Design, analysis and reporting of multi-arm trials and strategies to address multiple testing
Bằng: Odutayo, A, et al.
Được phát hành: (2020)

The use of placebo in a trial of rectal artesunate as initial treatment for severe malaria patients en route to referral clinics: ethical issues
Bằng: Kitua, A, et al.
Được phát hành: (2010)

A longitudinal assessment of trial protocols approved by research ethics committees: the Adherance to SPIrit REcommendations in the UK (ASPIRE-UK) study
Bằng: Speich, B, et al.
Được phát hành: (2022)

A systematic survey of randomised trials that stopped early for reasons of futility
Bằng: S. D. Walter, et al.
Được phát hành: (2020-01-01)

Acetylcholinesterase inhibitors combined with memantine for moderate to severe Alzheimer's disease: a meta-analysis
Bằng: Dominik Glinz, et al.
Được phát hành: (2019-06-01)