Quiescience as a mechanism for cyclical hypoxia and acidosis
Tumour tissue characteristically experiences fluctuations in substrate supply. This unstable microenvironment drives constitutive metabolic changes within cellular populations and, ultimately, leads to a more aggressive phenotype. Previously, variations in substrate levels were assumed to occur thro...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
2007
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