Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

<p>The response to hypoxia in animals involves the expression of multiple genes regulated by the αβ-hypoxia inducible transcription factors (HIFs). The hypoxia sensing mechanism involves oxygen limited hydroxylation of prolyl-residues in the <em>N</em>- and <em>C</em>-t...

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Bibliographic Details
Main Authors: Chowdhury, R, Leung, I, Tian, Y, Abboud, M, Ge, W, Domene, C, Cantrelle, F, Landrieu, I, Hardy, A, Pugh, C, Ratcliffe, P, Claridge, T, Schofield, C
Format: Journal article
Published: Nature Publishing Group 2016

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