Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales

Medical countermeasures to treat biothreat agent infections require broad-spectrum therapeutics that do not induce agent resistance. A cell-based high-throughput screen (HTS) against ricin toxin combined with hit optimization allowed selection of a family of compounds that meet these requirements. T...

Full description

Bibliographic Details
Main Authors:	Gupta, N, Noël, R, Goudet, A, Hinsinger, K, Michau, A, Pons, V, Abdelkafi, H, Secher, T, Shima, A, Shtanko, O, Sakurai, Y, Cojean, S, Pomel, S, Liévin-Le Moal, V, Leignel, V, Herweg, J, Fischer, A, Johannes, L, Harrison, K, Beard, P, Clayette, P, Le Grand, R, Rayner, J, Rudel, T, Vacus, J, Loiseau, P, Davey, R, Oswald, E, Cintrat, J, Barbier, J, Gillet, D
Format:	Journal article
Published:	Elsevier 2016

Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales

Similar Items