NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors
<p>There are no clinically useful inhibitors of metallo-Β-lactamases (MBLs), which are a growing problem because they hydrolyse almost all Β-lactam antibacterials. Inhibition by most reported MBL inhibitors involves zinc ion chelation. A structure-based virtual screening approach combined with...
| Asıl Yazarlar: | , , , , , , , , , |
|---|---|
| Materyal Türü: | Journal article |
| Baskı/Yayın Bilgisi: |
Royal Society of Chemistry
2017
|