NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors
<p>There are no clinically useful inhibitors of metallo-Β-lactamases (MBLs), which are a growing problem because they hydrolyse almost all Β-lactam antibacterials. Inhibition by most reported MBL inhibitors involves zinc ion chelation. A structure-based virtual screening approach combined with...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Royal Society of Chemistry
2017
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