NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors

<p>There are no clinically useful inhibitors of metallo-Β-lactamases (MBLs), which are a growing problem because they hydrolyse almost all Β-lactam antibacterials. Inhibition by most reported MBL inhibitors involves zinc ion chelation. A structure-based virtual screening approach combined with...

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Bibliographic Details
Main Authors:	Li, G, Abboud, M, Brem, J, Someya, H, Lohans, C, Yang, S, Spencer, J, Wareham, D, McDonough, M, Schofield, C
Format:	Journal article
Published:	Royal Society of Chemistry 2017

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