Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

Polycomb Repressor Complexes (PRCs) are important regulators of embryogenesis. In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promoters for PRC1, PRC2 and Ser 5-phosphorylated RNA Polymerase II (RNAP), and contain domains of 'bivalen...

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Bibliographic Details
Main Authors: Landeira, D, Sauer, S, Poot, R, Dvorkina, M, Mazzarella, L, Jørgensen, H, Pereira, C, Leleu, M, Piccolo, F, Spivakov, M, Brookes, E, Pombo, A, Fisher, C, Skarnes, W, Snoek, T, Bezstarosti, K, Demmers, J, Klose, R, Casanova, M, Tavares, L, Brockdorff, N, Merkenschlager, M, Fisher, A
Format: Journal article
Language:English
Published: 2010

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