Analysis of genome architecture during SCNT reveals a role of cohesin in impeding minor ZGA

Somatic cell nuclear transfer (SCNT) can reprogram a somatic nucleus to a totipotent state. However, the re-organization of 3D chromatin structure in this process remains poorly understood. Using low-input Hi-C, we revealed that, during SCNT, the transferred nucleus first enters a mitotic-like state...

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Detalhes bibliográficos
Principais autores:	Zhang, K, Wu, D-Y, Zheng, H, Wang, Y, Sun, Q-R, Liu, X, Wang, L-Y, Xiong, W-J, Wang, Q, Rhodes, JDP, Xu, K, Li, L, Lin, Z, Yu, G, Xia, W, Huang, B, Du, Z, Yao, Y, Nasmyth, KA, Klose, RJ, Miao, Y-L, Xie, W
Formato:	Journal article
Idioma:	English
Publicado em:	Cell Press 2020

Analysis of genome architecture during SCNT reveals a role of cohesin in impeding minor ZGA

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